SCI
30April
AssociationofRivaroxabanWithThromboembolicEventsinPatientsWithHeartFailure,CoronaryDisease,andSinusRhythm
GreenbergB,NeatonJD,AnkerSD,etal.AssociationofRivaroxabanWithThromboembolicEventsinPatientsWithHeartFailure,CoronaryDisease,andSinusRhythm:APostHocAnalysisoftheCOMMANDERHFTrial.JAMACardiol.
CorrespondingAuthor:BarryGreenberg,MD,CardiologyDivision,DepartmentofMedicine,UniversityofCalifornia,SanDiego,MedicalCenterDr,LaJolla,CA-(bgreenberg
ucsd.edu).IMPORTANCE重要性
Whetheranticoagulationbenefitspatientswithheartfailure(HF)insinusrhythmisuncertain.TheCOMMANDERHFrandomizedclinicaltrialevaluatedtheeffectsofaddinglow-doserivaroxabantoantiplatelettherapyinpatientswithrecentworseningofchronicHFwithreducedejectionfraction,coronaryarterydisease(CAD),andsinusrhythm.Althoughtheprimaryendpointofallcausemortality,myocardialinfarction,orstrokedidnotdifferbetweenrivaroxabanandplacebo,therewerenumericaladvantagesfavoringrivaroxabanformyocardialinfarctionandstroke.
抗凝治疗对心衰(HF)患者窦性心律是否有益尚不清楚。COMMANDERHF随机临床试验评估了低剂量利伐沙班联合抗血小板治疗近期慢性心衰加重伴射血分数降低、冠状动脉疾病(CAD)及窦性心律的疗效。尽管利伐沙班和安慰剂在全因死亡率、心肌梗死或卒中的主要终点上并无差异，但对心肌梗死和卒中在数据上仍有优势。
OBJECTIVE目标
Toexaminewhetherlow-doserivaroxabanwasassociatedwithreducedthromboemboliceventsinpatientsenrolledintheCOMMANDERHFtrial.
研究在纳入COMMANDERHF试验的患者中，低剂量利伐沙班是否与血栓栓塞事件发生率降低有关。
DESIGN,SETTING,ANDPARTICIPANTS设计，设置及参与者
PosthocanalysisoftheCOMMANDERHFmulticenter,randomized,double-blind,placebo-controlledtrialinpatientswithCADandworseningHF.ThetrialrandomizedpatientspostdischargefromahospitaloroutpatientclinicaftertreatmentforworseningHFbetweenSeptemberandOctober.PatientswererequiredtobereceivingstandardcareforHFandCADandwereexcludedforamedicalconditionrequiringanticoagulationorableedinghistory.Patientswererandomizedina1:1ratio.AnalysiswasconductedfromJuneandJanuary.
COMMANDERHF的多中心，随机，双盲，安慰剂对照试验，对冠心病和HF恶化患者的事后分析。本试验随机选取了年9月至年10月期间在接受治疗后出院或门诊的例HF恶化患者。患者被要求接受HF和CAD的标准治疗，且需要抗凝或有出血史的患者被排除在外。患者按1:1的比例随机分组。分析是从年6月到年1月进行的。
INTERVENTION干预
Patientswererandomlyassignedtoreceive2.5mgofrivaroxabangivenorallytwicedailyorplaceboinadditiontotheirstandardtherapy.
患者被随机分配每天两次口服2.5毫克利伐沙班，或在标准治疗的基础上服用安慰剂。
MAINOUTCOMESANDMEASURES主要结果及措施
Forthisposthocanalysis,athromboembolic乌鲁木齐治白癜风最好的医院白癜风应如何治疗
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